Digoxin increases the risk of death in patients with heart problems.

"There is conflicting evidence about whether digoxin, a drug that has been used worldwide for centuries to treat heart disease, might contribute to an increase in deaths in patients with atrial fibrillation (AF) or congestive heart failure (CHF). Now, the largest review of all the evidence to date shows that it is associated with an increased risk of death in these patients, particularly in those being treated for AF. In a study published online in the European Heart Journal, researchers from the J.W. Goethe University in Frankfurt, Germany, conducted a systematic review and meta–analysis of all studies published in peer–reviewed journals between 1993–2014 that looked at the effects of digoxin on death from any cause in AF and CHF patients. They identified 19 relevant studies that included a total of 326,426 patients (235,047 AF and 91,379 CHF patients). They found that among patients who were treated with digoxin, there was an overall 21% increased risk of death from any cause compared to patients who were not receiving this treatment. When they looked at the group of AF patients and the group of CHF patients separately, digoxin was associated with a 29% and 14% increased risk of death from any cause respectively, when compared to patients not receiving the drug."
European Society of Cardiology