Feb. 2nd, 2016

mim0za: (Default)
"Ten percent of individuals worldwide are affected by autoimmune diseases, with systemic lupus erythematosus (SLE) being one of the most common.1 Drug-induced lupus erythematosus (DILE) was first recognized in 1945 with sulfadiazine as the offending agent.2 Since then, more than 90 medications from more than 10 drug classes have been implicated in causing lupus.1,3 DILE is estimated to affect 15,000 to 20,000 individuals each year and accounts for 10% of SLE cases.1,2 Risk factors for DILE include being a slow acetylator, having certain serologic features (eg, HLA-DR4 and HLADR0301), having complement C4 null allele, and being female.2

Drug-Induced Lupus Erythematosus
DILE is similar to idiopathic SLE. However, the prognosis of DILE is promising compared with that of SLE. DILE presents itself after exposure to the offending medication and the symptoms usually resolve within weeks of discontinuing the offending agent"
http://www.pharmacytimes.com/publications/issue/2016/January2016/Drug-Induced-Autoimmune-Diseases
mim0za: (Default)
"One factor that probably contributes to the variability of levothyroxine drug–drug interactions is that some individuals are completely dependent on exogenous levothyroxine (eg, following total thyroidectomy) while others have varying degrees of residual thyroid function. Those with some thyroid function may also have varying degrees of feedback stimulation of endogenous thyroid release via thyroidreleasing hormone and TSH."
http://www.pharmacytimes.com/publications/issue/2016/January2016/Drugs-Affecting-Levothyroxine-Absorption

Fenugreek

Feb. 2nd, 2016 11:39 pm
mim0za: (Default)
"Reduction in cataract incidence has been demonstrated in diabetic rats receiving an extract of fenugreek seeds and leaves. 28 After 115 days of treatment, cataracts were diagnosed in 25% of fenugreek recipients compared with 100% of diabetic controls. Oral administration of fenugreek seed fractions resulted in dose-dependent gastric protection against the effects of ethanol (a necrotizing agent). 29 The seeds were as effective as omeprazole, a clinically-recognized antiulcer agent. Ulcer scores indicated that the soluble gel fraction was more effective than the aqueous extract or omeprazole."
http://www.drugs.com/npp/fenugreek.html

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